A team of researchers from the Perelman School of Medicine at the University of Pennsylvania have shed new light on how the structure of regulatory sequences in DNA is packaged in a cell. “This work has implications for better understanding the role that gene sequences called enhancers play within our DNA for governing gene activity,” said senior author Ken Zaret, PhD, a professor of Cell and Developmental Biology and director of the Institute for Regenerative Medicine. The findings are published […]
Ben Z. Stanger, MD, PhD, an associate professor of Medicine and associate investigator of the Abramson Family Cancer Research Institute was elected to the Association of American Physicians (AAP), a nonprofit, professional society for physicians dedicated to the pursuit and advancement of medical knowledge. Stanger and his lab study how cells acquire their specialized features and their ability to adapt to new roles when given exposure to new, different conditions. His work has focused on gastrointestinal cancer and tissue regeneration. […]
Every cell in the body has two genomes, one from the mother and one from the father. Until now, researchers have lacked the tools to examine — in a single cell –the exact readout from each genome to make RNA. Using a new technology that allows researchers to do just that, an interdisciplinary University of Pennsylvania team examined a rare disease in which these two genomes are expressed differently throughout the body, even sometimes in the same organ. They found […]