Job Openings

Postdoctoral Researcher, Mir Lab

The Mir lab at the University of Pennsylvania (UPenn) and the Children’s Hospital of Philadelphia (CHOP) has openings for two fully funded postdoctoral scholars. In brief, the Mir lab develops and applies advanced light microscopy technologies, including single molecule imaging and light-sheet microscopy, to study the regulation of gene expression in the context of embryonic development and disease models. We are deeply interested in the relationship between the molecular scale dynamics of nuclear organization and how they shape and are shaped by transcription.

We offer a fast-paced, multi-disciplinary environment, in a brand-new lab and office space with access to state-of-the art microscopy and molecular biology facilities. We are a part of both CHOP and the School of Medicine at Penn and as a result access to a tremendous amount of intellectual capital and potential for both basic science and translational collaborations. We are situated in the heart of Philadelphia which offers all the advantages of living in a big historical city along (food, culture, museums, arts, easy access to outdoorsy things) along with affordable housing and good public transit. As a lab we are committed to doing bold, rigorous, open, and curiosity driven science. We actively strive to be communicative, empathetic, inclusive, and kind.

We are seeking individuals interested in one (or combinations) of the following research directions. If you don’t feel like you fit into of these interest areas but are still interested in the labs research please do not hesitate to apply:

-Apply lattice light-sheet microscopy and single molecule tracking methods in combination with genomics and biochemical assays to address questions in the areas of transcription regulation and nuclear organization.

-Develop new imaging hardware for multi-modal live imaging, label-free contrast, and hyperspectral imaging.

-Develop new computational tools and biophysical models to extract quantitative information from large multi-dimensional imaging data sets, single molecule trajectories, and live imaging of transcription.

If interested, please email Dr. Mir (mirm@chop.edu) with your CV, a brief description of your research interests, past and current research experience, future career goals, and contact information for at least 3 references.

Please visit www.mir-lab.com or reach out at mirm@chop.edu for more details.

Postdoctoral Researcher, Bi Lab

The Bi lab in the Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania is seeking two highly motivated postdocs, starting on July 1^st, 2021, to conduct NIH-funded research on the mechanisms of hepatocyte polarization and apical tube formation using a rat hepatocyte cell line.  The same problems will be addressed in parallel using the mouse model by an outstanding collaborator.  The newly recruited postdocs will work in a highly supportive and interactive environment with others who study the mechanisms of cytokinesis and septin assembly and remodeling using both budding yeast and mammalian cells as the experimental systems.  All the questions in the Bi lab have been addressed using an integrative approach that combines gene editing, advanced imaging, and biochemical analysis.  Recent publications can be found at https://cdb.med.upenn.edu/people/erfei-bi/.

Candidates with a Ph.D. in any biomedical science-related fields are encouraged to apply.  Preference will be given to those with experience in CRISPR/Cas9-based gene editing and live-cell imaging in mammalian cells.  Please send your CV and arrange for 2-3 recommendation letters to be sent directly to Dr. Erfei Bi (ebi@pennmedicine.upenn.edu).

Postdoctoral Researcher, Plachta Lab